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Aberrations in Circulating Ceramide Levels Are Associated with Poor Clinical Outcomes Across Localised and Metastatic Prostate Cancer by Hui-Ming Lin; Kevin Huynh; Manish Kohli; Winston Tan; Arun A. Azad; Nicole Yeung; Kate L. Mahon; Blossom Mak; Peter D. Sutherland; Andrew Shepherd; Natalie Mellett; Maria Docanto; Corey Giles; Margaret M. Centenera; Lisa M. Butler; Peter J. Meikle; Lisa G. Horvath is a Medicine article available to read on EtoBox.
What is Aberrations in Circulating Ceramide Levels Are Associated with Poor Clinical Outcomes Across Localised and Metastatic Prostate Cancer about?
Background Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC). The primary aim of the study is to assess the relationship between the plasma lipidome and clinical outcomes in localised and metastatic PC. The secondary aim is to validate a prognostic circulating 3-lipid signature specific to metastatic castration-resistant PC (mCRPC). Patients and methods Comprehensive lipidomic analysis was performed on pre-treatment plasma samples from men with localised PC (N = 389), metastatic hormone-sensitive PC (mHSPC)(N = 44), or mCRPC (validation cohort, N = 137). Clinical outcomes from our previously published mCRPC cohort (N = 159) that was used to derive the prognostic circulating 3-lipid signature, were updated. Associations between circulating lipids and clinical outcomes were examined by Cox regression and latent class analysis. Results Circulating lipid profiles featuring elevated levels of ceramide species were associated with metastatic relapse in localised PC (HR 5.80, 95% CI 3.04-11.1, P = 1 × 10 -6 ), earlier testosterone suppression failure in mHSPC (HR 3.70, 95% CI 1.37-10.0, P = 0.01), and shorter overall su
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- Author
- Hui-Ming Lin; Kevin Huynh; Manish Kohli; Winston Tan; Arun A. Azad; Nicole Yeung; Kate L. Mahon; Blossom Mak; Peter D. Sutherland; Andrew Shepherd; Natalie Mellett; Maria Docanto; Corey Giles; Margaret M. Centenera; Lisa M. Butler; Peter J. Meikle; Lisa G. Horvath
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)