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What is Eco-Friendly Synthesis of Bis(Indoles) about?
The document describes an efficient method for synthesizing bis(indole) derivatives by reacting indole with electron-deficient alkenes in water using zirconium oxychloride supported on silica (ZrOCl2·SiO2) as a catalyst. Various reaction conditions were optimized, finding that refluxing the reaction mixture in water with 20 mol% ZrOCl2·SiO2 catalyst gave bis(indole) products in high yields. Both electron-donating and electron-withdrawing substituents on the alkene substrates were tolerated. When pyridylmalo
- Author
- Walid Ebid Elgammal
- Language
- EN