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Can I read Mitochondrial Transplantation Improves Anxiety- and Depression-like Behaviors in Aged Stress-exposed Rats on EtoBox?
Mitochondrial Transplantation Improves Anxiety- and Depression-like Behaviors in Aged Stress-exposed Rats by Gonja Javani; Shirin Babri; Fereshteh Farajdokht; Arshad Ghaffari-Nasab; Gisou Mohaddes is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondrial Transplantation Improves Anxiety- and Depression-like Behaviors in Aged Stress-exposed Rats about?
Impaired mitochondrial function and abnormalities in the tryptophan (Trp)-kynurenine (Kyn) pathway are linked to age-related mood disorders. This study investigated the effect of intracerebroventricular (ICV) injection of the mitochondria isolated from young rat brain on depression-like behaviors of aged rats subjected to chronic mild stress (CMS). Aged (22 months old) male rats were randomly assigned into four groups: Aged, Aged + Mit, Aged + CMS, and Aged + CMS + Mit. Anxiety- and depression-like behaviors were assessed using elevated plus maze (EPM), open field test (OFT), forced swimming test (FST), and sucrose preference test (SPT). Mitochondrial membrane potential (MMP), ATP levels, indoleamine 2, 3-dioxygenase (IDO) levels, and Kyn metabolites were measured in the prefrontal cortex (PFC). Golgi Cox staining was used to investigate the neuronal morphology. Mitotherapy decreased immobility time and anhedonia in the FST; increased open arm time and entries in the EPM; decreased grooming and increased rearing, center time, and the entrance in the OFT. Mitotherapy also reduced IDO and Kyn metabolites, restored MMP and ATP production, and enhanced dendritic length and spine densit
Who reads Mitochondrial Transplantation Improves Anxiety- and Depression-like Behaviors in Aged Stress-exposed Rats?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gonja Javani; Shirin Babri; Fereshteh Farajdokht; Arshad Ghaffari-Nasab; Gisou Mohaddes
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)