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Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway by Labanyamoy Kole; Mrinmoy Sarkar; Anwesha Deb; Biplab Giri is a Neuroscience article available to read on EtoBox.

What is Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway about?

## Background: The thiazolidinedione (tzd) class of peroxisome proliferator-activated receptor gamma (ppar-γ) ligands are known for their ability to induce adipocyte differentiation, to increase insulin sensitivity including anticancer properties. but, whether or not upstream events like mapk activation or ppar-γ signaling are involved or associated with this anticancer activity is not well understood in breast cancer cells. the role of mapk and ppar pathways during the pioglitazone (pio) induced ppar-γ independent anticancer activity in mcf7 cells has been focused here. ## Methods: The anticancer activity of pio has been investigated in breast cancer cells in vitro. anti-tumor effects were assessed by alamar blue assay, western blot analysis, cell cycle analysis, and annexin v-fitc/pi binding assay by flow cytometry, hoechst staining and luciferase assay. ## Results: The anticancer activity of pio is found to be correlating with the up regulation of cdkis (p21/p27) and down regulation of cdk-4. this study demonstrates that the induction of cdkis by pio is due to the sustained activation of mapk. the pio-mediated activation of mapk is transmitted to activate elk-1 and the related a

Who reads Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway?

Author

Labanyamoy Kole; Mrinmoy Sarkar; Anwesha Deb; Biplab Giri

Published

2016

Language

EN

Field

Neuroscience (Life Sciences)