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In Vivo Microscopy of Microcirculatory Injury in Skeletal Muscle Following Ischemia/reperfusion by Dr. Mark Pemberton; Gary Anderson; John Barker is a Medicine article available to read on EtoBox.

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## Abstract While the sequence of biochemical and cellular events in the pathogenesis of ischemia/reperfusion injury is increasingly well understood, the way that these processes interact at the level of microcirculation to promote a distinctive reperfusion injury is less well defined. It is becoming clear, however, that these processes are initiated at the level of microcirculation, and that microcirculatory damage may precede actual tissue injury. Such damage causes microvascular no‐reflow, which in turn effectively prolongs the time of tissue ischemia and extends tissue injury. Recently, microcirculatory models have been adapted for study of the microvascular effects of ischemia/reperfusion. We have used a new in vivo mouse cremaster muscle model to study, by direct and quantitative measurement, the acute microvascular changes involved in ischemia/reperfusion. Previously described changes in capillary perfusion and venular leukocyte adhesion were observed in this model following reperfusion after prolonged ischemia (4–6 hours). We have further characterized an intense reactive vasoconstriction or vasospasm that occurs after prolonged ischemia; this vessel reaction may represent

Who reads In Vivo Microscopy of Microcirculatory Injury in Skeletal Muscle Following Ischemia/reperfusion?

Author

Dr. Mark Pemberton; Gary Anderson; John Barker

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)

Published

1994

Language

EN

Field

Medicine (Health Sciences)