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Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway by Wei, MingBo; Wu, YanLi; Liu, Hui; Xie, Chun is a Medicine article available to read on EtoBox.

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## Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, and it accounts for more than 90% of oral cancer. Due to high mortality, limitations of traditional treatment and many complications, new treatment methods are urgently needed. This study aimed to look into the effect of new potential anti-tumor drug, genipin, on OSCC treatment. ## Methods In vitro, CCK-8, colony formation, and flow cytometry were used to detect the effect of genipin on SCC-9 and SCC-15 cell lines. Immunofluorescence, real-time PCR, and Western blotting were used to investigate its mechanism. Xenograft tumor model was used to explore the role of genipin in vivo. ## Results We found that genipin suppressed cell growth and induced apoptosis in vitro. In addition, the expression of p62 was down-regulated while Beclin1 and LC3II were up-regulated in SCC-25 and SCC-9 cells. 3-methyladenine (3-MA) significantly decreased LC3 (LC3II)^+^ puncta, but genipin rescuect 3d this reduction. Furthermore, genipin also reduced the expression of p-PI3K, p-AKT, and p-mTOR. In vivo experiment showed that genipin significantly curbed the tumor size and weight. The positive expression of

Who reads Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway?

Author

Wei, MingBo; Wu, YanLi; Liu, Hui; Xie, Chun

Publisher

Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.: Dove Medical Press, 2007]-; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1177-8881)

Published

2020

Language

EN

Field

Medicine (Health Sciences)