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Assessing Ocular Toxicology in Laboratory Animals 4 Preface 8 Acknowledgements 10 Contents 12 Contributors 14 Chapter 1: Comparative Ocular Anatomy in Commonly Used Laboratory Animals 16 Chapter 2: Assessment of Ocular Toxicity Potential: Basic Theory and Techniques 37 Chapter 3: Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals 67 Chapter 4: Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals 136 Chapter 5: Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment 171 Chapter 6: Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment 230 Chapter 7: Nonclinical Regulatory Aspects for Ophthalmic Drugs 269 Chapter 8: Ocular Toxicity Regulatory Considerations for Nondrug Food and Drug Administration (FDA) Products and the Environmental Protection Agency (EPA) 305 About the Editors 316 Index 317
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