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Heparin‐induced Thrombocytopenia and Thrombosis: a Prospective Analysis of the Incidence in Patients with Heart and Cerebrovascular Diseases by M. C. Kappers-Klunne; D. M. S. Boon; W. C. J. Hop; J. J. Michiels; J. Stibbe; C. Van Der Zwaan; P. J. Koudstaal; H. H. D. M. Van Vliet is a Medicine article available to read on EtoBox.
What is Heparin‐induced Thrombocytopenia and Thrombosis: a Prospective Analysis of the Incidence in Patients with Heart and Cerebrovascular Diseases about?
Heparin‐induced thrombocytopenia and/or thrombosis (HITT) are serious complications of heparin treatment. The incidence, as previously reported, varies widely and, in consequence, is not precisely known. Moreover, most reports only concern clinically defined heparin‐induced thrombocytopenia. Therefore we carried out a prospective study of the incidence of serologically confirmed HITT. All patients admitted to the Departments of Cardiology and Neurology of our institution with an indication for treatment with therapeutic‐dose intravenous unfractionated heparin were enrolled in the study. The patients were examined daily for the occurrence of thromboembolic complications. Regular platelet counts and tests for the presence of heparin‐dependent antibodies were carried out using two different tests: a quantitative platelet factor 4/heparin (PF4/hep) Elisa, and a functional test, the heparin‐induced platelet activation assay (HIPAA). HITT was defined as a rapidly occurring (within 5 d) decrease of the platelet count from normal values of >120 ×10^9^ l to <60 ×10^9^ l or to 50% of starting value or >30% with concomitant acute thrombosis. The observed incidence of HITT was 1/358 patients
Who reads Heparin‐induced Thrombocytopenia and Thrombosis: a Prospective Analysis of the Incidence in Patients with Heart and Cerebrovascular Diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- M. C. Kappers-Klunne; D. M. S. Boon; W. C. J. Hop; J. J. Michiels; J. Stibbe; C. Van Der Zwaan; P. J. Koudstaal; H. H. D. M. Van Vliet
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)