Can I read The Role of Autophagy in Regulating Metabolism in the Tumor Microenvironment on EtoBox?

The Role of Autophagy in Regulating Metabolism in the Tumor Microenvironment by Panpan Zhang; Shanshan Cheng; Xiaonan Sheng; Huijuan Dai; Kang He; Yueyao Du is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Role of Autophagy in Regulating Metabolism in the Tumor Microenvironment about?

Autophagy, as a special programmed cell death, is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related (ATG) proteins. Autophagy activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment (TME) which comprises of tumor cells, cancer-associated fibroblasts (CAFs), cancer-associated endothelial cells (CAEs), immune cells and adipocytes. Tumor cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and proliferation. However, the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not clear. Reprogramed metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse mechanisms. The activation of autophagy has expanded our understanding on the interaction between tumor metabolism and TME. The aim of this review is to report recent advances on the metabolic cross-talk between stromal cells a

Who reads The Role of Autophagy in Regulating Metabolism in the Tumor Microenvironment?

Author

Panpan Zhang; Shanshan Cheng; Xiaonan Sheng; Huijuan Dai; Kang He; Yueyao Du

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)