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Glycolytic dysregulation in Alzheimer’s disease: unveiling new avenues for understanding pathogenesis and improving therapy by You Wu, Lijie Yang, Wanrong Jiang, Xinyuan Zhang, Zhaohui Yao is a book available to read on EtoBox.

What is Glycolytic dysregulation in Alzheimer’s disease: unveiling new avenues for understanding pathogenesis and improving therapy about?

Alzheimer’s disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments. The current therapeutic strategies, primarily based on cholinesterase inhibitors and N-methyl-DDate of acceptance: June 20, 2024 aspartate receptor antagonists, offer limited symptomatic relief without halting disease Date of web publication: July 29, 2024 progression, highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer’s disease. Recent studies have provided insights From the Contentsinto the critical role of glycolysis, a fundamental energy metabolism pathway in the brain, in the pathogenesis of Alzheimer’s disease. Alterations in glycolytic processes Introduction 2264within neurons and glial cells, including microglia, astrocytes, and oligodendrocytes, have Retrieval Strategy 2266been identified as significant contributors to the pathological landscape of Alzheimer’s disease. Glycolytic changes impact neuronal health and function, thus offering promising Glycolysis in the Brain 2266targets for therapeutic intervention. The purpose of this review is to consolidate curr

Author

You Wu, Lijie Yang, Wanrong Jiang, Xinyuan Zhang, Zhaohui Yao

Published

2025

Language

EN