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Association of Serine/threonine Kinase 11 Mutations and Response to Programmed Cell Death 1 Inhibitors in Metastatic Gastric Cancer by Kwon, Minsuk; Hong, Jung Yong; Kim, Seung Tae; Kim, Kyoung-Mee; Lee, Jeeyun is a Medicine article available to read on EtoBox.

What is Association of Serine/threonine Kinase 11 Mutations and Response to Programmed Cell Death 1 Inhibitors in Metastatic Gastric Cancer about?

Programmed cell death 1 (PD-1) inhibitors have shown therapeutic efficacy in metastatic gastric cancer (mGC). However, no predictive biomarkers have been established in mGC. Inactivating mutations in serine/threonine kinase 11 (STK11) are associated with poor response to PD-1 inhibitors in KRAS-mutant lung adenocarcinoma. Therefore, we hypothesized that STK11 inactivating mutations would be associated with inferior clinical response to PD-1 inhibitors in mGC. We analyzed 59 mGC patients who had been treated with PD-1 inhibitors and whose tumors had been analyzed by targeted high-throughput sequencing. STK11 mutations were identified in 30 (50.8%) patients, and were all missense mutations. Three patients (5.1%) had STK11 gene amplification and mutation, simultaneously. Patients with STK11 mutations had prolonged overall survival (median: 19.0 vs 11.6 months, p = 0.15), and progression-free survival (4.2 vs 1.9 months, p = 0.06) when treated with PD-1 inhibitors, but these differences were not statistically significant. Patients with STK11 inactivating mutations without STK11 gene amplification had significantly prolonged progression-free survival compared to patients with wild type

Who reads Association of Serine/threonine Kinase 11 Mutations and Response to Programmed Cell Death 1 Inhibitors in Metastatic Gastric Cancer?

Author

Kwon, Minsuk; Hong, Jung Yong; Kim, Seung Tae; Kim, Kyoung-Mee; Lee, Jeeyun

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0344-0338)

Published

2020

Language

EN

Field

Medicine (Health Sciences)