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Effect of Haptoglobin Phenotypes on Growth of Streptococcus pyogenes by Joris Delanghe; Michel Langlois; Jin Ouyang; Geert Claeys; Marc De Buyzere; Birgitte Wuyts is a Medicine article available to read on EtoBox.

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## Abstract The haptoglobin (Hp) 2–1 and 2–2 phenotypes have been shown to agglutinate__Streptococcus pyogenes__carrying the membrane antigen T4. In this study, the growth rate of two strains of__Streptococcus pyogenes__(T1 and T4) in human serum was compared among haptoglobin phenotypes__in vitro__. During incubation for 16 hours in serum of different haptoglobin types, only Hp 2–1 and Hp 2–2 sera showed an inhibitory effect on growth, Hp 2–2 being 1.85 times more potent than Hp 2–1. Growth of__Streptococcus pyogenes__T4 negatively correlated with the serum concentration of Hp 2–1 (r = −0.908) and Hp 2–2 (r = −0.953). Haptoglobin-depleted serum had no inhibitory effect on bacterial growth. Addition of haemoglobin and ferric citrate to the serum accelerated the growth of__Streptococcus pyogenes__T4 (P < 0.05) but not in Hp 2–2 serum. Haptoglobin types 2–1 and 2–2 can be regarded as inhibitors of__Streptococcus pyogenes__growth__in vitro__. These data point towards a potential protective role of Hp 2–2 in__Streptococcus pyogenes__infection__in vivo__, independently of iron uptake.

Who reads Effect of Haptoglobin Phenotypes on Growth of Streptococcus pyogenes?

Author

Joris Delanghe; Michel Langlois; Jin Ouyang; Geert Claeys; Marc De Buyzere; Birgitte Wuyts

Publisher

Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 1434-6621)

Published

1998

Language

EN

Field

Medicine (Health Sciences)