Can I read Predicting the Ancestral Character Changes in a Tree Is Typically Easier Than Predicting the Root State on EtoBox?

Predicting the Ancestral Character Changes in a Tree Is Typically Easier Than Predicting the Root State by Gascuel, Olivier; Steel, Mike is a scholarly article available to read on EtoBox.

What is Predicting the Ancestral Character Changes in a Tree Is Typically Easier Than Predicting the Root State about?

Predicting the ancestral sequences of a group of homologous sequences related by a phylogenetic tree has been the subject of many studies, and numerous methods have been proposed to this purpose. Theoretical results are available that show that when the mutation rate become too large, reconstructing the ancestral state at the tree root is no longer feasible. Here, we also study the reconstruction of the ancestral changes that occurred along the tree edges. We show that, depending on the tree and branch length distribution, reconstructing these changes (i.e. reconstructing the ancestral state of all internal nodes in the tree) may be easier or harder than reconstructing the ancestral root state. However, results from information theory indicate that for the standard Yule tree, the task of reconstructing internal node states remains feasible, even for very high substitution rates. Moreover, computer simulations demonstrate that for more complex trees and scenarios, this result still holds. For a large variety of counting, parsimony-based and likelihood-based methods, the predictive accuracy of a randomly selected internal node in the tree is indeed much higher than the accuracy of th

Author

Gascuel, Olivier; Steel, Mike

Published

2013

Language

EN