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Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database by Lu, Yen-Chu; Yang, Ching-Wei; Lin, Yi-Hsuan; Hsueh, Ju-Yu; Chen, Jiun-Liang; Yang, Sien-Hung; Chen, Yu-Chun; Chen, Hsing-Yu; Koo, Malcolm is a Medicine article available to read on EtoBox.

What is Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database about?

Background and Purpose. Allergic rhinitis (AR) is a highly prevalent disease, and Chinese herbal medicine (CHM) is commonly used for treating AR. This study aims to demonstrate the CHM network for AR and possible molecular pathways. Materials and Methods. Patients with a primary diagnosis of AR (ICD-9-CM code: 477.9) in 2010 were included, and the National Health Insurance Research Database in Taiwan was used as the data source. Association rule mining and social network analysis were used to establish and explore the CHM network. Possible molecular pathways of the CHM network were summarized and compared with commonly used western medicine (WM) by conducting overrepresentation analysis in the Reactome pathway database. The potential proteins acted by CHMs were obtained from the CHM ingredient-protein databases, including STITCH, TCMSP, TCMID, and TCM@Taiwan. Results. There were 89,148 AR subjects found in 2010, and a total of 33,507 patients ever used CHM. On an average, 5.6 types of CHMs were utilized per prescription. Xin-Yi-Qing-Fei-Tang was used most frequently (25.5% of 222,279 prescriptions), while Xiao-Qing-Long-Tang with Xin-Yi-San was the most commonly prescribed CHM-CHM

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Author

Lu, Yen-Chu; Yang, Ching-Wei; Lin, Yi-Hsuan; Hsueh, Ju-Yu; Chen, Jiun-Liang; Yang, Sien-Hung; Chen, Yu-Chun; Chen, Hsing-Yu; Koo, Malcolm

Publisher

Oxford University Press; Hindawi Limited; Hindawi Publishing Corporation; Oxford: Oxford University Press, 2004-; New York: Hindawi; London: Hindawi (ISSN 1741-427X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)