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This document describes a one-step synthesis of C-C linked aryl-heterocycles or heteroaryl-heterocycles from anionically activated trifluoromethyl groups. The method involves reacting substrates containing anionically activated trifluoromethyl groups with amino nucleophiles in sodium hydroxide. This produces various nitrogen-containing heterocycles in good to excellent yields under mild aqueous conditions.

Author

Isai Marlo

Language

EN