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Ultrastructure of gap junction and Cx43 expression in gastric cancer tissues of the patients by Li, Chun-Hui; Hao, Mei-Ling; Sun, Yu; Wang, Zhu-Jun; Li, Jian-Ling is a Medicine article available to read on EtoBox.

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## Introduction Gap junctions are intercellular channels formed by connexin facilitating communication between cells by allowing transfer of ions and small signaling molecules. Connexin 43 (Cx43) is the most ubiquitous connexin in human tissues. Ample evidence suggests the role of gap junction and its connexins such as connexin 43 in human cancers including gastric cancer, which has an important place in the worldwide incidence of cancer and cancer-related deaths. Due to a number of contradictory studies and insufficient detailed examination in specific cancers, such as gastric cancer, more data on the role of gap junctions and their connexins such as Cx43 involved in gastric cancer remain necessary. ## Material and methods Transmission electron microscopy, Western blotting and RT-PCR were used to show the ultrastructure damage of the gap junction in the gastric carcinoma tissue as well as the expression of Cx43 protein and mRNA, respectively. ## Results Ultrastructure damage of the gap junction in gastric carcinoma tissue was shown while poorly differentiated tissue experienced greater damage. The expression of Cx43 protein and mRNA was higher in healthy gastric tissue than in car

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Author

Li, Chun-Hui; Hao, Mei-Ling; Sun, Yu; Wang, Zhu-Jun; Li, Jian-Ling

Publisher

Termedia Publishing House; Termedia Sp. z.o.o.; Termedia Publishing House Ltd.; Poznań: "Termedia" Publishing House (ISSN 1734-1922)

Published

2020

Language

EN

Field

Medicine (Health Sciences)