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Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy? by Cosmo Godino; Loredana Mendolicchio; Filippo Figini; Azeem Latib; Andrew SP Sharp; John Cosgrave; Giliola Calori; Michela Cera; Alaide Chieffo; Alfredo Castelli; Attilio Maseri; Zaverio M Ruggeri; Antonio Colombo is a Medicine article available to read on EtoBox.

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## Background: Dual anti-platelet therapy with aspirin and a thienopyridine (dat) is used to prevent stent thrombosis after percutaneous coronary intervention (pci). low response to clopidogrel therapy (lr) occurs, but laboratory tests have a controversial role in the identification of this condition. ## Methods: We studied lr in patients with stable angina undergoing elective pci, all on dat for at least 7 days, by comparing: 1) flow cytometry (fc) to measure platelet membrane expression of p-selectin (cd62p) and pac-1 binding following double stimulation with adp and collagen type i either in the presence of prostaglandin (pg) e1; 2) verifynow-p2y12 test, in which results are reported as absolute p2y12-reaction-units (pru) or % of inhibition (% inhibition). ## Results: Thirty controls and 52 patients were analyzed. the median percentage of platelets exhibiting cd62p expression and pac-1 binding by fc evaluation after stimulation in the presence of pg e1 was 25.4% (iqr: 21.4-33.1%) and 3.5% (1.7-9.4%), respectively. only 6 patients receiving dat (11.5%) had both values above the 1st quartile of controls, and were defined as lr. evaluation of the same patients with the verifynow-p2

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Author

Cosmo Godino; Loredana Mendolicchio; Filippo Figini; Azeem Latib; Andrew SP Sharp; John Cosgrave; Giliola Calori; Michela Cera; Alaide Chieffo; Alfredo Castelli; Attilio Maseri; Zaverio M Ruggeri; Antonio Colombo

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1477-9560)

Published

2009

Language

EN

Field

Medicine (Health Sciences)