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Polyester Scaffolds with Bimodal Pore Size Distribution for Tissue Engineering by Stanislaw Sosnowski; Piotr Woźniak; Małgorzata Lewandowska‐Szumieł is a Materials Science article available to read on EtoBox.

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## Abstract **Summary:** This paper presents a method for the preparation of porous poly(L‐lactide)/poly[(L‐lactide)‐__co__‐glycolide] scaffolds for tissue engineering. Scaffolds were prepared by a mold pressing‐salt leaching technique from structured microparticles. The total porosity was in the range 70–85%. The pore size distribution was bimodal. Large pores, susceptible for osteoblasts growth and proliferation had the dimensions 50–400 μm. Small pores, dedicated to the diffusion of nutrients or/and metabolites of bone forming cells, as well as the products of hydrolysis of polyesters from the walls of the scaffold, had sizes in the range 2 nm–5 μm. The scaffolds had good mechanical strength (compressive modulus equal to 41 MPa and a strength of 1.64 MPa for 74% porosity). Scaffolds were tested __in vitro__ with human osteoblast‐like cells (MG‐63). It was found that the viability of cells seeded within the scaffolds obtained using the mold pressing‐salt leaching technique from structured microparticles was better when compared to cells cultured in scaffolds obtained by traditional methods. After 34 d of culture, cells within the tested scaffolds were organized in a tissue‐like s

Who reads Polyester Scaffolds with Bimodal Pore Size Distribution for Tissue Engineering?

Author

Stanislaw Sosnowski; Piotr Woźniak; Małgorzata Lewandowska‐Szumieł

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)

Published

2006

Language

EN

Field

Materials Science (Physical Sciences)