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Action of serotonin in the medial prefrontal cortex: Mediation by serotonin~3~‐like receptors by Charles R. Ashby Jr.; Emmeline Edwards; Rex Y. Wang is a Neuroscience article available to read on EtoBox.

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## Abstract In the present study, we investigated the effects of various serotonin (5‐HT) antagonists on 5‐HT's action on medial prefrontal cortical cells (mPFc) using the techniques of single cell recording and microintophoretic The microiontophoretic application of 5‐HT (10–80 nA) produced a current‐dependent suppression of mPFc cell firing and this effect was blocked by the selective 5‐HT~3~ receptor antagonists (±)‐zacopride, ICS 205930 and granisetron at currents of 5–20 nA. Furthermore, the intravenous (i.v.) administration of (±)‐zacopride (5–50 μg/kg) markedly attenuates the suppressive action of 5‐HT on mPFc cell firing. In contrast, the microinotophoresis of 5‐HT~1~ and 5‐HT~2~ receptor antgonists such as (±)‐pindolol, spiperone, metergoline, and ritanserin (10–20 nA) failed to block 5‐HT's effect. In fact, in some cells, spiperone and ritanserin potentiated 5‐HT's action and prolonged neuronal recovery. In addition, the intravenous administration of either ritanserin (5–2,000 μg/kg) or metergoline (4–2,400 μg/kg) failed to alter 5‐HT's action. The electrical stimulation of the caudal linear raphe nucleus (CLi) suppressed the spontaneous activity of 83% of the mPFc cells

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Author

Charles R. Ashby Jr.; Emmeline Edwards; Rex Y. Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)