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Using beagle dogs, researchers developed an animal model to evaluate the effects of chronic cigarette smoking on pulmonary function, defense, and morphology. Dogs were exposed to cigarette smoke for 6 months or 1 year using an apparatus. Exposure caused impairment of tracheal mucociliary transport and macrophage function, with little change in lung function. Morphological changes were seen in airways.

Author

Brando

Language

EN