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Gene-environment Interaction Tests for Dichotomous Traits in Trios and Sibships by Thomas J. Hoffmann; Christoph Lange; Stijn Vansteelandt; Nan M. Laird is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Gene-environment Interaction Tests for Dichotomous Traits in Trios and Sibships about?

## Abstract When testing for genetic effects, failure to account for a gene‐environment interaction can mask the true association effects of a genetic marker with disease. Family‐based association tests are popular because they are completely robust to population substructure and model misspecification. However, when testing for an interaction, failure to model the main genetic effect correctly can lead to spurious results. Here we propose a family‐based test for interaction that is robust to model misspecification, but still sensitive to an interaction effect, and can handle continuous covariates and missing parents. We extend the FBAT‐I gene‐environment interaction test for dichotomous traits to using both trios and sibships. We then compare this extension to joint tests of gene and gene‐environment interaction, and compare the joint test additionally to the main effects test of the gene. Lastly, we apply these three tests to a group of nuclear families ascertained according to affection with Bipolar Disorder. __Genet. Epidemiol__. 33:691–699, 2009. © 2009 Wiley‐Liss, Inc.

Who reads Gene-environment Interaction Tests for Dichotomous Traits in Trios and Sibships?

Author

Thomas J. Hoffmann; Christoph Lange; Stijn Vansteelandt; Nan M. Laird

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)