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Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles by Racané, Livio; ButkoviÄ, Kristina; Martin-Kleiner, Irena; Kralj, Marijeta; Karminski-Zamola, Grace; Hranjec, Marijana is a Chemistry article available to read on EtoBox.
What is Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles about?
Within this work we describe the synthesis of versatile substituted 2-phenyl benzothiazole 3–10 and 2-phenylbenzimidazole 12–19 derivatives bearing amidino groups. Furthermore, the synthesized compounds were explored for their antiproliferative activity in vitro on three cancer cell lines. Tested compounds showed moderate to strong antiproliferative activity. Furthermore, the type of the attached amidino group on benzazole nuclei has the significant impact on the antiproliferative activity only within benzimidazole derivatives with 2-imidazolinyl substituted derivatives being more active in comparison to amidino substituted analogues. All obtained results revealed that this type of benzothiazole derivatives have a great potential for further optimization and development of more efficient potential antiproliferative agents.
Who reads Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Racané, Livio; ButkoviÄ, Kristina; Martin-Kleiner, Irena; Kralj, Marijeta; Karminski-Zamola, Grace; Hranjec, Marijana
- Publisher
- Portal of Scientific Journals of Croatia; Croatian Chemical Society; Hrvatsko Kemijsko Drustvo/Croatian Chemical Society; Zagreb: The Croatian Chemical Society (ISSN 0011-1643)
- Published
- 2019
- Language
- EN
- Field
- Chemistry (Physical Sciences)