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The Role of Extracellular Vesicles from Different Origin in the Microenvironment of Head and Neck Cancers by Xie, Changqing; Ji, Ning; Tang, Zhangui; Li, Jing; Chen, Qianming is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Role of Extracellular Vesicles from Different Origin in the Microenvironment of Head and Neck Cancers about?

The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the TME. Initially considered "garbage dumpsters" and later referred to as "signal boxes", EVs carry "cargo" (proteins, lipids, or nucleic acids) that can redirect the function of a recipient cell. Currently, the molecular mechanisms and clinical applications of EVs in head and neck cancers (HNCs) are still at an early stage and need to be further investigate. In this review, we provide insight into the TME of HNCs, classifying and summarizing EVs derived from different cell types and illuminating their complex signaling networks involved in mediating tumor proliferation, invasion and metastasis, vascular angiogenesis and cancer drug resistance. In addition, we highlight the application of EVs in HNCs, underlining the special pathological and physiological environment of HNCs. The application of tumor heterogeneous EVs in saliva and circulating blood diagnostics will provide a new pers

Who reads The Role of Extracellular Vesicles from Different Origin in the Microenvironment of Head and Neck Cancers?

Author

Xie, Changqing; Ji, Ning; Tang, Zhangui; Li, Jing; Chen, Qianming

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1476-4598)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)