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Protein-based Hybrid Catalysts—design and Evolution by Valentin Köhler; Yvonne M Wilson; Cheikh Lo; Alessia Sardo; Thomas R Ward is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Protein-based Hybrid Catalysts—design and Evolution about?

Artificial metalloenzymes result from the introduction of a catalytically competent non-native metal cofactor within a protein environment. In the present contribution, we summarize the recent achievements in the design and the optimization of such protein-based hybrid catalysts, with an emphasis on enantioselective transformations. The second part outlines the milestones required to achieve en masse production, screening and directed evolution of artificial metalloenzymes. In the spirit of Darwinian evolution, this will allow the full potential of such protein-based hybrid catalysts to be fully unraveled, thus complementing both homogeneous and enzymatic catalysis.

Who reads Protein-based Hybrid Catalysts—design and Evolution?

Author

Valentin Köhler; Yvonne M Wilson; Cheikh Lo; Alessia Sardo; Thomas R Ward

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0958-1669)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)