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What is Agonist-Bound Structures of CB1 Receptor about?
The article presents two crystal structures of the human cannabinoid receptor CB1 in complex with the agonists AM11542 and AM841, revealing significant conformational changes compared to the antagonist-bound state. These structures provide insights into the activation mechanism of CB1, highlighting a twin toggle switch essential for receptor activation and the plasticity of the binding pocket. The findings may inform the design of diverse ligands with distinct pharmacological properties.
- Author
- peroxid.1987
- Language
- EN