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Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Obese Children by Aysun Bideci; Peyami Cinaz; Alev Hasanoglu; Sehri Elbeg is a Medicine article available to read on EtoBox.

What is Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Obese Children about?

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) metabolism may be disturbed in obese children. We investigated serum GH, IGF-I, IGF-binding protein-3 (IGFBP-3) levels in 42 obese and 40 non-obese healthy children aged 6-14 years. GH stimulation tests with L-dopa and insulin were performed. Serum IGF-I levels were studied by immunoradiometric assay (IRMA) and IGFBP-3 levels by radioimmunoassay (RIA). IGF-I levels were significantly higher in the obese group (p<0.05), but IGFBP-3 levels were not different from the control group. IGF-I and IGFBP-3 levels were significantly higher in the obese pubertal children than in the obese prepubertal ones (p<0.05). A positive linear correlation was found between body mass index (BMI) and IGF-I levels (r=0.51, p<0.05). These results suggest that obesity may have a considerable effect on IGF-I.

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Author

Aysun Bideci; Peyami Cinaz; Alev Hasanoglu; Sehri Elbeg

Publisher

Walter de Gruyter GmbH

Published

1997

Language

EN

Field

Medicine (Health Sciences)