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Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG\* study in 380 patients by Teresa Amaral; Felix Kiecker; Sarah Schaefer; Henner Stege; Katharina Kaehler; Patrick Terheyden; Anja Gesierich; Ralf Gutzmer; Sebastian Haferkamp; Jochen Uttikal; Carola Berking; David Rafei-Shamsabadi; Lydia Reinhardt; Friedegund Meier; Ante Karoglan; Christian Posch; Thilo Gambichler; Claudia Pfoehler; Kai Thoms; Julia Tietze; Dirk Debus; Rudolf Herbst; Steffen Emmert; Carmen Loquai; Jessica C Hassel; Frank Meiss; Thomas Tueting; Vanessa Heinrich; Thomas Eigentler; Claus Garbe; Lisa Zimmer is a Medicine article available to read on EtoBox.

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## Background Nivolumab combined with ipilimumab have shown activity in melanoma brain metastasis (MBM). However, in most of the clinical trials investigating immunotherapy in this subgroup, patients with symptomatic MBM and/or prior local brain radiotherapy were excluded. We studied the efficacy of nivolumab plus ipilimumab alone or in combination with local therapies regardless of treatment line in patients with asymptomatic and symptomatic MBM. ## Methods Patients with MBM treated with nivolumab plus ipilimumab in 23 German Skin Cancer Centers between April 2015 and October 2018 were investigated. Overall survival (OS) was evaluated by Kaplan-Meier estimator and univariate and multivariate Cox proportional hazard analyses were performed to determine prognostic factors associated with OS. ## Results Three hundred and eighty patients were included in this study and 31% had symptomatic MBM (60/193 with data available) at the time of start nivolumab plus ipilimumab. The median follow-up was 18 months and the 2 years and 3 years OS rates were 41% and 30%, respectively. We identified the following independently significant prognostic factors for OS: elevated serum lactate dehydrogenas

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Author

Teresa Amaral; Felix Kiecker; Sarah Schaefer; Henner Stege; Katharina Kaehler; Patrick Terheyden; Anja Gesierich; Ralf Gutzmer; Sebastian Haferkamp; Jochen Uttikal; Carola Berking; David Rafei-Shamsabadi; Lydia Reinhardt; Friedegund Meier; Ante Karoglan; Christian Posch; Thilo Gambichler; Claudia Pfoehler; Kai Thoms; Julia Tietze; Dirk Debus; Rudolf Herbst; Steffen Emmert; Carmen Loquai; Jessica C Hassel; Frank Meiss; Thomas Tueting; Vanessa Heinrich; Thomas Eigentler; Claus Garbe; Lisa Zimmer

Published

2020

Language

EN

Field

Medicine (Health Sciences)