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What is Extended-Spectrum β-Lactamase Mechanisms about?

This review discusses the structural and mechanistic basis for extended-spectrum drug-resistance mutations in TEM, CTX-M, and KPC β-lactamases, which are key enzymes in the resistance of Gram-negative bacteria to β-lactam antibiotics. It highlights how mutations in these enzymes enhance their ability to hydrolyze newer oxyimino-cephalosporins, leading to increased antibiotic resistance. The review also explores the kinetic mechanisms of these enzymes and the evolutionary pressures that drive the emergence o

Author

Rubén Agudo Torres

Language

EN