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Can I read Proteome Profiling Reveals Gender Differences in the Composition of Human Serum on EtoBox?
Proteome Profiling Reveals Gender Differences in the Composition of Human Serum by Koichiro Miike; Masashi Aoki; Ryo Yamashita; Yumiko Takegawa; Hideyuki Saya; Teruhisa Miike; Ken‐ichi Yamamura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Proteome Profiling Reveals Gender Differences in the Composition of Human Serum about?
## Abstract Proteome analysis using human serum is a technological advancement that will enable the discovery of novel biomarkers and biomarker patterns of various human diseases. Although proteome analysis using serum has potential in disease prevention, early diagnosis and treatment of diseases, and evaluation of pharmacotherapies, this technology is still in its infancy. Thus, we sought to develop an advanced method of conducting proteome analysis on human serum. In this study, we report the development of the semi‐comprehensive protein analytical technique, which involves the systematic use of iTRAQ labeling, HPLC, nano‐LC and MS. We compared the composition of the serum proteome in males and females using this technique and detected gender‐based differences in serum protein composition. This technology will enable the generation of databases that may ultimately lead to the discovery of specific biomarkers or biomarker patterns of various diseases.
Who reads Proteome Profiling Reveals Gender Differences in the Composition of Human Serum?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Koichiro Miike; Masashi Aoki; Ryo Yamashita; Yumiko Takegawa; Hideyuki Saya; Teruhisa Miike; Ken‐ichi Yamamura
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)