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This study investigates the impact of catecholamine stress on diastolic function and myocardial energetics in obese individuals compared to normal-weight subjects. It finds that obesity is associated with impaired cardiac energetics and diastolic dysfunction, which worsens under acute stress, as indicated by a significant reduction in the phosphocreatine/ATP ratio and peak filling rate during dobutamine stress. The findings suggest that myocardial energetics play a crucial role in the diastolic dysfunction

Author

Shaban Alramlawy

Language

EN