Can I read Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa on EtoBox?

Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa by Frances L. Chadbourne; Catriona Raleigh; Hayder Z. Ali; Paul W. Denny; Steven L. Cobb is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa about?

## Abstract Given the paucity and toxicity of available drugs for leishmaniasis, coupled with the advent of drug resistance, the discovery of new therapies for this neglected tropical disease is recognised as being of the utmost urgency. As such antimicrobial peptides (AMPs) have been proposed as promising compounds against the causative __Leishmania__ species, insect vector‐borne protozoan parasites. Here the AMP temporins A, B and 1Sa have been synthesised and screened for activity against __Leishmania mexicana__ insect stage promastigotes and mammalian stage amastigotes, a significant cause of human cutaneous disease. In contrast to previous studies with other species the activity of these AMPs against __L. mexicana__ amastigotes was low. This suggests that amastigotes from different __Leishmania__ species display varying susceptibility to peptides from the temporin family, perhaps indicating differences in their surface structure, the proposed target of these AMPs. In contrast, insect stage __L. mexicana__ promastigotes were sensitive to two of the screened temporins which clearly demonstrates the importance of screening AMPs against both forms of the parasite. Copyright © 2011

Who reads Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa?

Author

Frances L. Chadbourne; Catriona Raleigh; Hayder Z. Ali; Paul W. Denny; Steven L. Cobb

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)