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Outcomes of Partial Oral Antibiotic Treatment for Complicated Staphylococcus aureus Bacteremia in People Who Inject Drugs by John A Wildenthal; Andrew Atkinson; Sophia Lewis; Sena Sayood; Nathanial S Nolan; Nicolo L Cabrera; Jonas Marschall; Michael J Durkin; Laura R Marks is a Medicine article available to read on EtoBox.
What is Outcomes of Partial Oral Antibiotic Treatment for Complicated Staphylococcus aureus Bacteremia in People Who Inject Drugs about?
## Abstract ## Background Staphylococcus aureus represents the leading cause of complicated bloodstream infections among persons who inject drugs (PWID). Standard of care (SOC) intravenous (IV) antibiotics result in high rates of treatment success but are not feasible for some PWID. Transition to oral antibiotics may represent an alternative treatment option. ## Methods We evaluated all adult patients with a history of injection drug use hospitalized from January 2016 through December 2021 with complicated S. aureus bloodstream infections, including infective endocarditis, epidural abscess, vertebral osteomyelitis, and septic arthritis. Patients were compared by antibiotic treatment (standard of care intravenous [SOC IV] antibiotics, incomplete IV therapy, or transition from initial IV to partial oral) using the primary composite endpoint of death or readmission from microbiologic failure within 90 days of discharge. ## Results Patients who received oral antibiotics after an incomplete IV antibiotic course were significantly less likely to experience microbiologic failure or death than patients discharged without oral antibiotics (P .9). ## Conclusions Discharge of PWID with part
Who reads Outcomes of Partial Oral Antibiotic Treatment for Complicated Staphylococcus aureus Bacteremia in People Who Inject Drugs?
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- Author
- John A Wildenthal; Andrew Atkinson; Sophia Lewis; Sena Sayood; Nathanial S Nolan; Nicolo L Cabrera; Jonas Marschall; Michael J Durkin; Laura R Marks
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)