Can I read Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China on EtoBox?

Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China by Yuting Yu; Zhiyu Luo; Weiping Jin; Jianyi Mai; Shasha Qian; Jia Lu; Zhenni Wei; Shengli Meng; Zejun Wang; Xuhua Guan; Yeqing Tong; Shuo Shen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China about?

Abstract Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997. Methods A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and sequencing. Among the 146 CV-A5 detected cases, the complete genome sequences of representative strains were determined for genotyping and for recombination analysis. Results It was found that CV-A5 was one of the six major serotypes that caused the epidemic from October 2016 to December 2017. Phylogenetic analyses based on the VP1 sequences showed that these CV-A5 belonged to the genotype D which dominantly circulated in China. Recombination occurred between the CV-A5 and CV-A2 strains with a breakpoint in the 2A region at the nucleotide 3791. Conclusions The result may explain the emergence of CV-A5 as one of the major pathogens of HFMD. A multivalent vaccine against HFMD is urgently needed to control the disease and to prevent emerging and spreading of new recombinants.

Who reads Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China?

Author

Yuting Yu; Zhiyu Luo; Weiping Jin; Jianyi Mai; Shasha Qian; Jia Lu; Zhenni Wei; Shengli Meng; Zejun Wang; Xuhua Guan; Yeqing Tong; Shuo Shen

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)