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UV-spectrophotometric determination of ampicillin sodium and sulbactam sodium in two-component mixtures by Hoda Mahgoub; Fatma Ahmed Aly is a Chemistry article available to read on EtoBox.
What is UV-spectrophotometric determination of ampicillin sodium and sulbactam sodium in two-component mixtures about?
A simple spectrophotometric method is used for the resolution of the binary mixtures of ampicillin sodium and sulbactam sodium. In aqueous solution, zero-order spectra are subject to interference, so first-derivative spectrophotometry was used to enhance the spectral details allowing the determination of ampicillin sodium from the signal at the zero-crossing point for sulbactam sodium at 268 nm. In 0.1 N sodium hydroxide, sulbactam sodium was determined from the absorbance at 260 nm with negligible contribution from ampicillin sodium. Also, sulbactam sodium was determined without interference using first-and second-derivative spectra in 0.1 N sodium hydroxide at 276 nm (peak-height) and 262-284 nm (peak-to-peak), respectively. The method is rapid, simple, does not require a separation step and allows the determination of each drug without interference from the other. The proposed method has been applied successfully to the assay of these drugs in mixtures and in commercial injections.
Who reads UV-spectrophotometric determination of ampicillin sodium and sulbactam sodium in two-component mixtures?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Hoda Mahgoub; Fatma Ahmed Aly
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 1998
- Language
- EN
- Field
- Chemistry (Physical Sciences)