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Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma by Taskeen Iqbal Janjua; Yuxue Cao; Aria Ahmed-Cox; Aun Raza; Md Moniruzzaman; Dewan Taslima Akhter; Nicholas L. Fletcher; Maria Kavallaris; Kristofer J. Thurecht; Amirali Popat is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma about?

The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field of neuro-oncology. The presence of the blood brain barrier (BBB) along with the highly invasive and aggressive nature of glioblastoma presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is a first line agent used in the clinic for glioblastoma and it has been useful in increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, such as a short plasma half-life (2 h), is subjected to P-gp efflux, and has limited extravasation from blood to brain (∼20%). It has been postulated that reducing its efflux and increasing glioblastoma tissue exposure to TMZ could prove useful in treating glioblastoma and preventing tumour recurrence. Herein, ultra-small, large pore silica nanoparticles (USLP) have been loaded with TMZ, surface PEGlyated to reduce efflux and decorated with the cascade targeting protein lactoferrin for efficient uptake across the BBB and into glioblastoma. Our results demonstrate that USLP improves permeability of BBB in vitro as evidenced using a transwell model which mimics endothelial tight j

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Author

Taskeen Iqbal Janjua; Yuxue Cao; Aria Ahmed-Cox; Aun Raza; Md Moniruzzaman; Dewan Taslima Akhter; Nicholas L. Fletcher; Maria Kavallaris; Kristofer J. Thurecht; Amirali Popat

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)