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Can I read Synthesis, design, in silico , in vitro and in vivo (streptozotocin-induced diabetes in mice) biological evaluation of novels N -arylacetamide derivatives on EtoBox?
Synthesis, design, in silico , in vitro and in vivo (streptozotocin-induced diabetes in mice) biological evaluation of novels N -arylacetamide derivatives by Salma Mortada; Walid Guerrab; Mohcine Missioui; Najoua Salhi; Hanae Naceiri Mrabti; Lamiaa Rouass; Souad Benkirane; Mamad Hassane; Azlarab Masrar; Hicham Mezzour; My El Abbes Faouzi; Youssef Ramli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis, design, in silico , in vitro and in vivo (streptozotocin-induced diabetes in mice) biological evaluation of novels N -arylacetamide derivatives about?
The organic compounds 2-chloro-N-(aryl)acetamide (Ps13-Ps18) and 2-azido-N-(aryl)acetamide (148-153) were synthesized and analyzed using 1 H, 13 C NMR. The acute oral toxicity study was carried out according to OECD guidelines, which approve that the compounds (Ps18 and 153) were nontoxic. In addition, the compounds were evaluated for its antidiabetic and antihyperglycemic properties (in vitro and in vivo) and for antioxidant activity by utilizing several tests as 1,1-diphenyl2-picrylhydrazyl DPPH, (2,2'-azino-bis(3-ethyl benzthiazoline-6-sulfonicacid) ABTS, reducing power test FRAP and hydrogen peroxide activity H 2 O 2 . The molecular docking studies were performed to investigate the antidiabetic activity of Ps18 and 153 and compared with the experimental results. These compounds are a potent antidiabetic from both the experimental and molecular docking results. Finally, the physicochemical, pharmacokinetic and toxicological properties of Ps18 and 153 have been evaluated by using in silico absorption, distribution, metabolism, excretion and toxicity analysis prediction.
Who reads Synthesis, design, in silico , in vitro and in vivo (streptozotocin-induced diabetes in mice) biological evaluation of novels N -arylacetamide derivatives?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Salma Mortada; Walid Guerrab; Mohcine Missioui; Najoua Salhi; Hanae Naceiri Mrabti; Lamiaa Rouass; Souad Benkirane; Mamad Hassane; Azlarab Masrar; Hicham Mezzour; My El Abbes Faouzi; Youssef Ramli
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)