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The Clinical Value of the Changes of Peripheral Lymphocyte Subsets Absolute Counts in Patients with Non-small Cell Lung Cancer by Ying Xia; Wentao Li; Yongmin Li; Yunhe Liu; Songshan Ye; Aqing Liu; Jianchun Yu; Yingjie Jia; Xu Liu; Huayu Chen; Yongtie Guo is a Medicine article available to read on EtoBox.
What is The Clinical Value of the Changes of Peripheral Lymphocyte Subsets Absolute Counts in Patients with Non-small Cell Lung Cancer about?
## Introduction Immune function strongly influences the outcome of patients with non-small cell lung cancer (NSCLC). It's vital to understand the immune state of patients through detecting the percentage and number of lymphocyte subsets accurately, and helpful to evaluate conditions of prognosis and adjust treatment for patients. ## Methods We conducted a retrospective cohort study in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. The absolute counts and percentages of CD3+, CD3 + CD4+, CD3 + CD8+, B and NK cells were determined by single platform technologies. 172 patients received treatment including surgery or chemotherapy after surgery. The factors affecting disease progression were analyzed by Binary Logistic regression. Progression free survival (PFS) calculating survivals were with the method of Kaplan-Meier. The log-rank test and cox's proportional hazard regression (enter method) were used for univariable and multivariable analyses respectively. ## Results Relative to normal controls, patients with NSCLC at different stages showed decreased absolute lymphocyte count obviously, rather than lymphocyte percentages. Different tre
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- Author
- Ying Xia; Wentao Li; Yongmin Li; Yunhe Liu; Songshan Ye; Aqing Liu; Jianchun Yu; Yingjie Jia; Xu Liu; Huayu Chen; Yongtie Guo
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)