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Test–retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers by Byrne, Christina; Kjaer, Andreas; Olsen, Naja Enevold; Forman, Julie Lyng; Hasbak, Philip is a Medicine article available to read on EtoBox.

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## Background: Myocardial flow reserve (mfr) assessment with cardiac positron emission computed tomography (pet/ct) is well established, and quantification relies on commercial software packages. however, for reliable use, repeatability and reproducibility are important. the aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of rb-pet/ct estimated mfr. ## Methods and results: Forty healthy volunteers completed two rb-pet/ct rest and adenosine stress scans. syngo.mbf (siemens), quantitative-gated spect (qgs) (cedars-sinai), and corridor4dm (4dm) were used for analyses. motion correction was available for 4dm. fifty percent were men and age was 24 ± 4 years (mean ± sd). repeatability of mfr varied between scans. syngo.mbf: mean difference (95% ci) 0.26 (- 0.03 to 0.54), p = 0.07, limits of agreement (loa): - 1.43 to 1.95; qgs: 0.19 (- 0.08 to 0.46), p = 0.15, loa: - 1.38 to 1.76; 4dm: 0.08 (- 0.17 to 0.34), p = 0.50, loa: - 1.37 to 1.53; and 4dm motion corrected: 0.17 (- 0.17 to 0.51), p = 0.32, loa: - 1.89 to 2.22. mfr was higher using 4dm +/- motion correction compared with syngo.mbf and qgs (all p <

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Author

Byrne, Christina; Kjaer, Andreas; Olsen, Naja Enevold; Forman, Julie Lyng; Hasbak, Philip

Publisher

Springer; Springer-Verlag; Springer New York LLC; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1071-3581)

Published

2020

Language

EN

Field

Medicine (Health Sciences)