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This document outlines protocols for assessing the release of mitochondrial DNA (mtDNA) into the cytosol and its role in activating innate immune pathways in mammalian cells. It discusses the significance of mtDNA as a damage-associated molecular pattern (DAMP) that triggers inflammatory responses, particularly through the cGAS-STING pathway. The article provides detailed methodologies for inducing mtDNA release, quantifying its presence, and analyzing the resulting immune responses, making it a valuable re

Author

Tanmay Jana

Language

EN