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Upregulation of Bradykinin Receptors Is Implicated in the Pain Associated with Caerulein‐induced Acute Pancreatitis by Yoshinori Takemura; Sadayoshi Furuta; Shigeto Hirayama; Kazuhiko Miyashita; Satoshi Imai; Michiko Narita; Naoko Kuzumaki; Yoshi Tsukiyama; Mitsuaki Yamazaki; Tsutomu Suzuki; Minoru Narita is a Neuroscience article available to read on EtoBox.
What is Upregulation of Bradykinin Receptors Is Implicated in the Pain Associated with Caerulein‐induced Acute Pancreatitis about?
Although the way for pain management associated with acute pancreatitis has been searched for, there are not enough medications available for it. The aim of the present study was to investigate the role of bradykinin (BK) in pain related to acute pancreatitis. After repeated injections of caerulein (50 lg/kg and 6 times), mice showed edema in the pancreas, and blood concentrations of pancreatic enzymes (amylase and lipase) were clearly elevated. A histopathological study demonstrated that caerulein caused tissue damage characterized by edema, acinar cell necrosis, interstitial hemorrhage, and inflammatory cell infiltrates. Furthermore, the mRNA levels of interleukin-1b and monocyte chemotactic protein (MCP)-1 were significantly increased in the pancreas of caerulein-treated mice. The sensitivity of abdominal organs as measured by abdominal balloon distension was enhanced in caerulein-injected mice, suggesting that caerulein caused pancreatic hyperalgesia. Moreover, repeated treatment with caerulein resulted in cutaneous tactile allodynia of the upper abdominal region as demonstrated by the use of von Frey filaments, indicating that caerulein-treated mice exhibited referred pain. Un
Who reads Upregulation of Bradykinin Receptors Is Implicated in the Pain Associated with Caerulein‐induced Acute Pancreatitis?
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- Author
- Yoshinori Takemura; Sadayoshi Furuta; Shigeto Hirayama; Kazuhiko Miyashita; Satoshi Imai; Michiko Narita; Naoko Kuzumaki; Yoshi Tsukiyama; Mitsuaki Yamazaki; Tsutomu Suzuki; Minoru Narita
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)