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Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration by Zhang, Huayu; Vreeken, Dianne; Junaid, Abidemi; Wang, Gangqi; Sol, Wendy M. P. J.; de Bruin, Ruben G.; van Zonneveld, Anton Jan; van Gils, Janine M. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration about?
In normal physiology, endothelial cells (ECs) form a vital barrier between the blood and underlying tissue controlling leukocyte diapedesis and vascular inflammation. Emerging data suggest that neuronal guidance cues, typically expressed during development, have roles outside the nervous system in vascular biology and immune responses. In particular, Class III semaphorins have been reported to affect EC migration and angiogenesis. While ECs express high levels of semaphorin 3F (SEMA3F), little is known about its function in mature ECs. Here we show that SEMA3F expression is reduced by inflammatory stimuli and increased by laminar flow. Endothelial cells exposed to laminar flow secrete SEMA3F, which subsequently binds to heparan sulfates on the surface of ECs. However, under pro-inflammatory conditions, reduced levels of SEMA3F make ECs more prone to monocyte diapedesis and display impaired barrier function as measured with an electric cell–substrate impedance sensing system and a microfluidic system. In addition, we demonstrate that SEMA3F can directly inhibit the migration of activated monocytes. Taken together, our data suggest an important homeostatic function for EC-expressed S
Who reads Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhang, Huayu; Vreeken, Dianne; Junaid, Abidemi; Wang, Gangqi; Sol, Wendy M. P. J.; de Bruin, Ruben G.; van Zonneveld, Anton Jan; van Gils, Janine M.
- Publisher
- Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI Center, 2000- (ISSN 1422-0067)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)