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Regulation of CD1d expression by murine tumor cells: Escape from immunosurveillance or alternate target molecules? by Tim Fiedler; Wolfgang Walter; Torsten E. Reichert; Markus J. Maeurer is a Medicine article available to read on EtoBox.

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## Abstract αβ+ TCR T cells recognize peptide fragments displayed by MHC‐class I or ‐class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1‐mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, __i.e__., the group II CD1 antigens, which are split into CD1D1 and CD1d2. Several T cell subsets have been shown to interact with murine CD1 antigens, including NK cells or “natural T cells” with the invariant Vα14 Jα281 TCR chain. Even if TAP defects may prevent classical endogenous antigen presentation in tumor cell lines, antigen presentation via CD1 is still functional. Therefore, CD1‐mediated recognition of transformed cells by NK cells or “natural T cells” may represent an alternative way for immune surveillance. CD1 cell surface expression in murine tumor cell lines of different histology, including the B cell lymphoma A20, macrophage cell lines J774 and P388D1, mastocytoma P815, thymoma EL‐4, melanoma B16, colon adenocarcinoma MC‐38 and renal carcinoma Renca is regulated by Th1‐ (IFN‐γ), Th2‐ (IL‐4, IL‐10 and vIL‐10) or GM‐CSF (Th1/Th2) cytokines, depending on t

Who reads Regulation of CD1d expression by murine tumor cells: Escape from immunosurveillance or alternate target molecules??

Author

Tim Fiedler; Wolfgang Walter; Torsten E. Reichert; Markus J. Maeurer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2002

Language

EN

Field

Medicine (Health Sciences)