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The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks by Xinxin Zhao; Hui Shen; Sheng Liang; Dekang Zhu; Mingshu Wang; Renyong Jia; Shun Chen; Mafeng Liu; Qiao Yang; Ying Wu; Shaqiu Zhang; Juan Huang; Xumin Ou; Sai Mao; Qun Gao; Ling Zhang; Yunya Liu; Yanling Yu; Leichang Pan; Anchun Cheng is a Medicine article available to read on EtoBox.
What is The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks about?
## Abstract Fowl cholera caused by Pasteurella multocida exerts a massive economic burden on the poultry industry. Lipopolysaccharide (LPS) is essential for the growth of P. multocida genotype L1 strains in chickens and specific truncations to the full length LPS structure can attenuate bacterial virulence. Here we further dissected the roles of the outer core transferase genes pcgD and hptE in bacterial resistance to duck serum, outer membrane permeability and virulence in ducks. Two P. multocida mutants, ΔpcgD and ΔhptE, were constructed, and silver staining confirmed that they all produced truncated LPS profiles. Inactivation of pcgD or hptE did not affect bacterial susceptibility to duck serum and outer membrane permeability but resulted in attenuated virulence in ducks to some extent. After high-dose inoculation, ΔpcgD showed remarkably reduced colonization levels in the blood and spleen but not in the lung and liver and caused decreased injuries in the spleen and liver compared with the wild-type strain. In contrast, the ΔhptE loads declined only in the blood, and ΔhptE infection caused decreased splenic lesions but also induced severe hepatic lesions. Furthermore, compared w
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- Author
- Xinxin Zhao; Hui Shen; Sheng Liang; Dekang Zhu; Mingshu Wang; Renyong Jia; Shun Chen; Mafeng Liu; Qiao Yang; Ying Wu; Shaqiu Zhang; Juan Huang; Xumin Ou; Sai Mao; Qun Gao; Ling Zhang; Yunya Liu; Yanling Yu; Leichang Pan; Anchun Cheng
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)