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Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction by Guy Bélanger; Mark A. Stocksley; Marie Vandromme; Laurent Schaeffer; Luc Furic; Luc DesGroseillers; Bernard J. Jasmin is a Neuroscience article available to read on EtoBox.
What is Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction about?
## Abstract Staufen is an RNA‐binding protein, first identified for its role in oogenesis and CNS development in __Drosophila__. Two mammalian homologs of Staufen have been identified and shown to bind double‐stranded RNA and tubulin, and to function in the somatodendritic transport of mRNA in neurons. Here, we examined whether Staufen proteins are expressed in skeletal muscle in relation to the neuromuscular junction. Immunofluorescence experiments revealed that Staufen1 (Stau1) and Staufen2 (Stau2) accumulate preferentially within the postsynaptic sarcoplasm of muscle fibers as well as at newly formed ectopic synapses. Western blot analyses showed that the levels of Stau1 and Stau2 are greater in slow muscles than in fast‐twitch muscles. Muscle denervation induced a significant increase in the expression of Stau1 and Stau2 in the extrasynaptic compartment of both fast and slow muscles. Consistent with these observations, we also demonstrated that expression of Stau1 and Stau2 is increased during myogenic differentiation and that treatment of myotubes with agrin and neuregulin induces a further increase in the expression of both Staufen proteins. We propose that Stau1 and Stau2 ar
Who reads Localization of the RNA-binding proteins Staufen1 and Staufen2 at the mammalian neuromuscular junction?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Guy Bélanger; Mark A. Stocksley; Marie Vandromme; Laurent Schaeffer; Luc Furic; Luc DesGroseillers; Bernard J. Jasmin
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)