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ABSTRACT 13Hyponatremia is the most common electrolyte disorder in hospital patients associated with14increased morbidity, mortality, hospital stay and financial burden. The speed of a correction15with 3% sodium chloride as 100 mL IV bolus or continuous infusion depends on the severity16and persistence of the symptoms, and needs frequent biochemical monitoring. The rapid17intermittent administration of hypertonic saline is preferred for treatment of symptomatic18hyponatremia. In asymptomatic mild hyponatremia, an adequate solute intake with an initial19fluid restriction (FR) of 500 mL/d adjusted according to the serum sodium levels is preferred.20Almost half of the syndrome of inappropriate diuresis hormone (SIADH) patients do not21respond to FR as first-line therapy. At present, urea and tolvaptan are considered as most22effective second-line therapies in SIADH. However, the evidence for guidance on the choice23of second-line therapy of hypotonic hyponatremia is lacking. Oral urea is considered as very24effective and safe treatment. Mild and asymptomatic hyponatremia is treated with25adequate solute intake (salt and protein) and an initial FR with adjustments based on serum26sodiu

Who reads Hyponatremia-treatment-standard-2024?

Author

Goce Spasovski

Publisher

Department of Nephrology, University of Skopje, Sts. Cyril and Methodius, Skopje, N. 6 Macedonia

Published

2024

Language

EN

Category

nonfiction

Subjects

Medical, Internal Medicine, Medicine