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Systematic Assessment of Plasma Biomarkers in Spinocerebellar Ataxia by Xue-Ning Shen; Kai-Min Wu; Yu-Yuan Huang; Yu Guo; Shu-Yi Huang; Ya-Ru Zhang; Shu-Fen Chen; Hui-Fu Wang; Wei Zhang; Wei Cheng; Mei Cui; Qiang Dong; Jin-Tai Yu is a Neuroscience article available to read on EtoBox.

What is Systematic Assessment of Plasma Biomarkers in Spinocerebellar Ataxia about?

Background and objectives Plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), phosphorylated-tau (p-tau), and β-amyloid (Aβ) have emerged as promising markers in several neurodegenerative disorders, but whether they can be used as biomarkers in spinocerebellar ataxias (SCA) is yet to be determined. This study aimed to identify sensitive plasma markers for SCA and investigate their effectiveness in tracking ataxia severity, cognition, non-motor symptoms, and brain atrophy. Methods This observational study recruited consecutive participants from Huashan Hospital and the CABLE study from November 2019. Patients with SCA were genetically diagnosed, grouped according to the ataxia severity, and compared with healthy older individuals and patients with multiple system atrophy type C (MSA-C). Plasma NfL, GFAP, p-tau, and Aβ levels were measured by Simoa in all participants. Analysis of covariance, Spearman correlation, and multivariable regression were used to explore candidate markers in SCA. Results A total of 190 participants (60 SCA, 56 MSA-C, and 74 healthy controls) were enrolled. Plasma NfL level increased early in the pre-ataxic stage of SCA (32.23 ± 3.07 vs.

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Author

Xue-Ning Shen; Kai-Min Wu; Yu-Yuan Huang; Yu Guo; Shu-Yi Huang; Ya-Ru Zhang; Shu-Fen Chen; Hui-Fu Wang; Wei Zhang; Wei Cheng; Mei Cui; Qiang Dong; Jin-Tai Yu

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)