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Comparative omics of CCM signaling complex (CSC) by Abou-Fadel, Johnathan; Smith, Mark; Falahati, Kamran; Zhang, Jun is a Medicine article available to read on EtoBox.

What is Comparative omics of CCM signaling complex (CSC) about?

## Abstract ## Background Cerebral cavernous malformations (CCMs), a major neurosurgical condition, characterized by abnormally dilated intracranial capillaries, result in increased susceptibility to stroke. KRIT1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3) have been identified as causes of CCMs in which at least one of them is disrupted in most familial cases. Our goal is to identify potential biomarkers and genetic modifiers of CCMs, using a global comparative omics approach across several in vitro studies and multiple in vivo animal models. We hypothesize that through analysis of the CSC utilizing various omics, we can identify potential biomarkers and genetic modifiers, by systemically evaluating effectors and binding partners of the CSC as well as second layer interactors. ## Methods We utilize a comparative omics approach analyzing multiple CCMs deficient animal models across nine independent studies at the genomic, transcriptomic, and proteomic levels to dissect alterations in various signaling cascades. ## Results Our analysis revealed a large set of genes that were validated across multiple independent studies, suggesting an important role for these identified genes in CCM p

Who reads Comparative omics of CCM signaling complex (CSC)?

Author

Abou-Fadel, Johnathan; Smith, Mark; Falahati, Kamran; Zhang, Jun

Publisher

Springer (Biomed Central Ltd.); London: BioMed Central, 2015-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 2057-4967)

Published

2020

Language

EN

Field

Medicine (Health Sciences)