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Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112) by Evgeny Vinogradov; Wayne J. Conlan; John S. Gunn; Malcolm B. Perry is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112) about?

Francisella novicida (U112), a close relative of the highly virulent bacterium F. tularensis, was shown to produce a lipopolysaccharide in which the antigenic O-polysaccharide component was found by chemical, 1H and 13C NMR and MS analyses to be an unbranched neutral linear polymer of a repeating tetrasaccharide unit composed of 2-acetamido-2-deoxy-D-galacturonamide (D-GalNAcAN) and 2,4-diacetamido-2,4,6-trideoxy-D-glucose (D-Qui2NAc4NAc, di-N-acetylbacillosamine) residues (3:1) and had the structure: -->4)-alpha-D-GalNAcAN-(1-->4)-alpha-D-GalNAcAN-(1-->4)-alpha-D-GalNAcAN-(1-->3)-alpha-D-QuiNAc4NAc-(1-->. With polyclonal murine antibody, the F. novicida O-antigen did not show serological cross-reactivity with the O-antigen of F. tularensis despite the occurrence of a common -->4)-D-GalpNAcAN-(1-->4)-alpha-D-GalpNAcAN-(1--> disaccharide unit in their respective O-antigens. Thus, O-PS serology offers a practical way to distinguish between the two Francisella species.

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Author

Evgeny Vinogradov; Wayne J. Conlan; John S. Gunn; Malcolm B. Perry

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)