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Construction and Evaluation of Hyaluronic Acid–Coated Flurbiprofen-Layered Double Hydroxide Ocular Drug Delivery System by Donghao Gu; Hao Pan; Shuo Xu; Wenyue Chen; Renfang Zhu; Wenjing Jiang; Weisan Pan is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Construction and Evaluation of Hyaluronic Acid–Coated Flurbiprofen-Layered Double Hydroxide Ocular Drug Delivery System about?

In this study, flurbiprofen (FB) was selected as the model drug, and hyaluronic acid-coated flurbiprofen-layered double hydroxide ophthalmic drug delivery system (HA-FB-LDH) was designed and prepared. In this system, the model drug flurbiprofen was intercalated in layered double hydroxide and coated with hyaluronic acid (HA), so as to prolong the corneal residence time and increase the corneal permeability of the drug. Layered double hydroxide (LDH) was prepared by alcohol-water coprecipitation method. Through single factor investigation, the optimum preparation conditions were obtained as follows: The Mg/Al ratio was 2:1, the reaction pH was 11.0, the hydrothermal reaction time was 24 h, and the hydrothermal reaction temperature was 100°C. Under these conditions, the particle size of LDH was 116.4 ± 0.8 nm, the potential was 42.2 ± 1.2 mV, and a relatively regular crystal structure could be had. Then FB was intercalated into the LDH layer to prepare flurbiprofen-layered double hydroxide (FB-LDH). In the end, HA-FB-LDH was prepared by the stirring-ultrasonic method, in which through prescription screening, the molecular weight of HA was 200-400 kDa and the concentration of HA solut

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Author

Donghao Gu; Hao Pan; Shuo Xu; Wenyue Chen; Renfang Zhu; Wenjing Jiang; Weisan Pan

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)