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Cell Cycle, Apoptosis, Cell Differentiation, and Lipid Metabolism Gene Expression in Endometriotic Tissue and Exposure to Parabens and Benzophenones by F.M. Peinado; A. Olivas-Martínez; L.M. Iribarne-Durán; A. Ubiña; J. León; F. Vela-Soria; J. Fernández-Parra; M.F. Fernández; N. Olea; C. Freire; O. Ocón-Hernández; F. Artacho-Cordón is a Environmental Science article available to read on EtoBox.

What is Cell Cycle, Apoptosis, Cell Differentiation, and Lipid Metabolism Gene Expression in Endometriotic Tissue and Exposure to Parabens and Benzophenones about?

Aim To describe the expression profile in endometriotic tissue of genes involved in four signaling pathways related to the development and progression of endometriosis (cell cycle, apoptosis, cell differentiation and lipid metabolism) and to explore its relationship with the women exposure to chemicals with hormonal activity released from cosmetics and personal care products (PCPs). Methods This cross-sectional study, encompassed within the EndEA study, comprised a subsample of 33 women with endometriosis. Expression levels of 13 genes (BMI1, CCNB1, CDK1, BAX, BCL2L1, FOXO3, SPP1, HOXA10, PDGFRA, SOX2, APOE, PLCG1 and PLCG2) in endometriotic tissue and urinary concentrations of 4 paraben (PB) and 3 benzophenone (BP) congeners were quantified. Bivariate linear and logistic regression analyses were performed to explore the associations between exposure and gene expression levels. Results A total of 8 out 13 genes (61.5 %) were expressed in >75 % of the samples. Exposure to congeners of PBs and/or BPs was associated with the overexpression of CDK1 gene (whose protein drives cells through G2 phase and mitosis), HOXA10 and PDGFRA genes (whose proteins favor pluripotent cell differentiat

Who reads Cell Cycle, Apoptosis, Cell Differentiation, and Lipid Metabolism Gene Expression in Endometriotic Tissue and Exposure to Parabens and Benzophenones?

Author

F.M. Peinado; A. Olivas-Martínez; L.M. Iribarne-Durán; A. Ubiña; J. León; F. Vela-Soria; J. Fernández-Parra; M.F. Fernández; N. Olea; C. Freire; O. Ocón-Hernández; F. Artacho-Cordón

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Environmental Science (Physical Sciences)